EUROMYASTHENIA [ www.euromyasthenia.org ] - Partenaires associés

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Le projet EuroMyasthenia

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Berrih-Aknin Sonia, France
De Baets Marc [en]

Gilhus Nils Erik [en]
Mantegazza Renato [en]
Marx Alexander [en]
Matell Ritva [en]
MDA-Hellas [en]
Tallaksen Chantal
TzartosSocrates [en]
Vincent [Angela en]

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Partenaires associés - Gilhus Nils Erik [en]

Nils Erik Gilhus

Nils Erik GILHUS

University of Bergen and Haukeland University Hospital
5021 Bergen
Norway
Phone : 47-559 750 00
Fax : 47-5597 5164

Clinico-immunological correlations in MG:

This team has defined antibodies against the non-acetylcholine receptor, intracellular muscle antigens titin and ryanodine receptor in some MG patients. Such muscle antibodies occur in paraneoplastic thymoma MG and late onset MG, and often indicate a more severe MG disease. Sensitisation against these antigens probably occurs in thymus through a combination of neoantigens and regulatory changes.

The team has examined the outcome for pregnancy, giving birth and the newborn when the mother has MG.
There is an increased need for control by obstetrician and neurologist during the pregnancy, but the outcome is generally favourable.
However, there is an increased risk for cesarean section, and approximately 20% of the babies develop a mild and transient neonatal MG due to passive transport of antibodies across the placenta. Arthrogryposis multiplex is a very rare complication.
Examination of the Norwegian death registry showed that up till 1995 there was an increased risk for death due to respiratory tract disease for MG patients. This difference is no longer present due to modern treatment. MG patients have a surprisingly low death rate due to malignant disease. Cardiac complications to MG seem to be insignificant.

Email address of Nils Erik GILHUS is available on request to the webmaster

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Date de création : 18/10/2006 - 4:36 PM
Dernière modification : 21/10/2008 - 4:30 PM
Catégorie : Partenaires associés
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